Effects of Epigallocatechin Gallate on Tert-Butyl Hydroperoxide-Induced Mitochondrial Dysfunction in Rat Liver Mitochondria and Hepatocytes.

Treatment with EGCG at a concentration of 50 μ M led to a higher level of State 4 leak respiration in isolated mitochondria ( p < 0.001 versus controls) and enhanced the tBHP-induced increase ( p < 0.001 versus tBHP alone); these differences did not reach statistical significance in permeabilized hepatocytes ( Figure 2 ).

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