Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans.

However, at 72 hours there was a pronounced reduction in the blister volume, with a slight trend toward reduced cell numbers in females — a reduction accounted for by a pronounced and significant reduction in inflammatory monocyte numbers.

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We did observe a trend toward enhanced IL-10 in the blisters of females at 24 hours; however, this did not reach statistical significance, likely due to the fact that the study was not powered for this measurement.

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