Drosophila poised enhancers are generated during tissue patterning with the help of repression.

Despite the variance, however, there was a significant trend for enhancers to have higher H3K27me3 levels in the uninduced versus active state ( P < 10 −2 , Wilcoxon rank-sum test) ( Fig. 3 B), consistent with previous findings ( Bonn et al. 2012 ).

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