For CD44 IHC, the cancer group showed a marked reduction in expression after eradication and resection, while the differences in the dysplasia and control groups did not reach statistical significance (control: 22.10 ± 8.70 to 20.31 ± 8.10, P = 0.304; dysplasia: 60.70 ± 10.51 to 49.79 ± 9.23, P = 0.081; cancer: 98.39 ± 12.37 to 45.68 ± 7.72, P = 0.013) ( Fig. 3D ).
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Expression of Leucine-rich Repeat-containing G-protein Coupled Receptor 5 and CD44: Potential Implications for Gastric Cancer Stem Cell Marker.
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LGR5 IHC score of gastric body showed an increasing trend according to the severity of IM (mild IM: 43.13 ± 8.33; moderate/severe IM: 57.60 ± 9.29, P for trends < 0.001) ( Fig. 4C–4E ). 6.