Polymorphisms in the GNAS Gene as Predictors of Ventricular Tachyarrhythmias and Sudden Cardiac Death: Results From the DISCOVERY Trial and Oregon Sudden Unexpected Death Study.

In the DISCOVERY trial, genotypes of 2 SNP s in the GNAS gene were nominally significant in the prospective screening and significantly associated with VT when viewed as recessive traits in post hoc analyses ( TT vs CC / CT in c.393C>T: HR 1.42 [ CI 1.11‐1.80], P =0.005; TT vs CC / CT in c.2273C>T: HR 1.57 [ CI 1.18‐2.09], P =0.002).

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