The PAV trial: does lactobacillus prevent post-antibiotic vulvovaginal candidiasis? Protocol of a randomised controlled trial [ISRCTN24141277].

BMC Fam Pract · 2004 · PMC521199 · PMID 15046642

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failed to reach statistical significanceno p-value reported

Most of these trials were methodologically poor (inadequate allocation concealment, not randomised, no controls and/or not intention-to-treat analysis) [ 15 - 18 ]; in the most recent trial in women with HIV, the lactobacillus arm failed to reach statistical significance in the prevention of vulvovaginal candidiasis [ 19 ].

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