In fact, although some miRNAs did not show a statistically significant difference in the expression levels between CLO and Barrett and between CLO and Esophagitis, there was a clear trend up or downregulation, under which the CLO appeared as intermediate step between Esophagitis and BE. miR-194 was found upregulated in patients with BE and with a lesser degree in patients with CLO while the expression levels of this miRNA did not change in patients with esophagitis.
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Analysis of tissue and circulating microRNA expression during metaplastic transformation of the esophagus.
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