Update on Lysinuric Protein Intolerance, a Multi-faceted Disease Retrospective cohort analysis from birth to adulthood.

Orphanet J Rare Dis · 2017 · PMC5217205 · PMID 28057010

Europe PMC DOI

hedged sentences

0.0800

closest p · 1.6× alpha

0.0800

boldest claim

The sentences

showed a trendp = 0.08so close (0.05 < p ≤ 0.1)

Age-adjusted plasma lysine concentrations at diagnosis showed a trend toward increased values in patients with a severe disease course and premature death (Wilcoxon p = 0.08; logrank, p = 0.17).

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borderline significantno p-value reported

Our data show a borderline significant association between relatively increased lysine levels (within normal to low values) and poor prognosis, calling for new investigations on the mechanisms of lysine transport and metabolism in LPI patients.

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