However, the C-statistic increment when adding hs-CRP to FRS did not reach statistical significance in predicting cardiovascular death, consistent with recommendations of the ACC/AHA that hs-CRP assessment should be reserved for those with uncertain risk defined by established qualitative methods (class IIb) 19 , and of the US Preventive Service Task Force not to use hs-CRP for routine screening of the general population 20 .
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Physical Health Indicators Improve Prediction of Cardiovascular and All-cause Mortality among Middle-Aged and Older People: a National Population-based Study.
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