Absence of system x_c^- on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis.

5b ), a strong trend for a significant difference in EAE clinical score could be detected 11 (xCT +/+ vs. xCT −/− BM mice: 0.75 ± 0.23 vs. 0.21 ± 0.12; p = 0.050; n = 13–14) and 14 days (xCT +/+ vs. xCT −/− BM mice: 3.31 ± 0.26 vs. 2.46 ± 0.21; p = 0.054; n = 13–14) after immunization, with a better outcome for mice lacking xCT in their immune cells (Fig. 5a ).

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