Cell-in-cell structures are more potent predictors of outcome than senescence or apoptosis in head and neck squamous cell carcinomas.

CIC formation turned out to be a highly significant predictor of overall-survival in pre-therapeutic biopsies ( p = 0.016), whereby a lack of CICs was beneficial for the patients (Fig. 4b ).

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The correlation between the three events was only weak and did not reach statistical significance (Fig. 3a-c ).

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