Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-β Peptide Generation In Vivo.

CSH for 21 days led to a ~2-fold increase of Vegfa mRNA levels in the brain of 2–3 month-old wild-type C57/Bl6J mice relative to control littermates exposed to the same chamber for the same period of time but at a 21% O 2 level (normoxia), although this change did not reach statistical significance.

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