Effectiveness and Tolerability of Different Recommended Doses of PPIs and H₂RAs in GERD: Network Meta-Analysis and GRADE system.

The majority of confounding factors did not reach statistical significance in all outcomes ( Supplementary Table S2 ), whereas gender (B = −0.127 (−0.225, −0.026), P = 0.010) and overall methodological quality score (B = −1.006 (−1.808, −0.213), P = 0.012) were significant for the main outcome; the year of publication for the tolerance (B = 0.028 (0.008, 0.049), P = 0.007) was also significant in consistent coefficients model.

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