Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signaling.

Mol Neurodegener · 2017 · PMC5248453 · PMID 28103901

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0.0010

closest p · 0.0× alpha

0.0010

boldest claim

The sentences

highly significantp < 0.001actually significant

Differences between values obtained in LRRK2 null cells following pathway activation and all other TOPflash values were highly significant in all cases (Fig. 2b-d and Additional file 4 : Figure S3A-B, p < 0.001; Additional file 4 : Figure S3C, p < 0.01).

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did not reach statistical significanceno p-value reported

6a ), although the effect of R1441C did not reach statistical significance.

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