The cumulative effect of this discrepancy in genome scale calculations could be quite significant, given that more than one third of the metabolic enzymes in S . cerevisiae are members of isoenzyme sets (and thus would end up incurring no cost whatsoever under standard FBA knockout calculations).
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Upon Accounting for the Impact of Isoenzyme Loss, Gene Deletion Costs Anticorrelate with Their Evolutionary Rates.
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