The seroprevalence of antithyroid peroxidase antibodies in bipolar families and bipolar twins: results from two longitudinal studies.

In a first study, among bipolar offspring (Dutch bipolar offspring: DBO) with a mean age of 21 years, a borderline significant ( p = .05) higher prevalence (9%) of TPO-Abs in the DBO cohort as compared to healthy population controls of the same age (3%) was observed, the prevalence being the highest especially in the daughters, who showed a prevalence of 11% in DBO compared to 4% in healthy controls ( p = .008).

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13.8%), but differences did not reach statistical significance ( p = .20) (Table 1 ).

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