The lack of association between angiotensin-converting enzyme gene insertion/deletion polymorphism and nicotine dependence in multiple sclerosis.

A slightly greater prevalence of nicotine dependence observed among male patients did not reach statistical significance ( p > .05, respectively); yet, data regarding smoking severity revealed significantly higher values of pack‐year smoking history and a significantly greater number of cigarettes smoked per day among male patients compared to females with MS ( p < .0001 in both cases, respectively) (Table 1 ).

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