Multivariate characterization of white matter heterogeneity in autism spectrum disorder.

SRS total raw score showed a positive relationship with D M (increased autism severity were associated with increased deviation from normal); however, this also did not reach statistical significance (r = 0.12, p = 0.27). 4 Discussion In this work, we have used the Mahalanobis distance (D M ) as a metric to characterize complex and subtle relationships of multivariate measures of individual brain microstructure within a longitudinal sample of individuals with autism spectrum disorder.

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