SUMO-specific protease 1 protects neurons from apoptotic death during transient brain ischemia/reperfusion.

However, using similar samples as that used for western to perform quantitative RT-PCR, we only detected moderate changes in SENP1 mRNA levels, which did not reach statistical significance ( Figure 1e ), suggesting that transcriptional mechanism did not play a major part in the upregulation of SENP1.

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