showed a trendP =0.0851
However, in the subgroup of analysis among vaccinated patients (n=55), the median survival of humoral responders showed a trend of improvement compared with non-responders (19.2 vs. 13.9 months; P =0.0851). 83 A study of 29 patients who had received p53 vaccine combined with chemotherapy treatments in ED-SCLC showed a high ORR.