Proteins Involved in HER2 Signalling Pathway, Their Relations and Influence on Metastasis-Free Survival in HER2-Positive Breast Cancer Patients Treated with Trastuzumab in Adjuvant Setting.

Higher Ki-67LI was observed in G3 and ER/PR immunonegative carcinomas (Table 3 ), however those relationships did not reach statistical significance .

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In a group treated with neoadjuvant chemotherapy and trastuzumab, negative relation (marginally significant) between pathological complete response and EGFR expression 37 was found, however, contradictory observation - more frequent progression in EGFR-negative group - also was made 36 .

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