When analyzing the suppressive capacity of Treg generated from 6 donors independently, a clear trend was observed that TAC reduced suppression of the naive Treg subpopulation in a larger proportion of donors compared with the CD25 int mTreg cell subpopulation (2-sided Fisher exact test: P = 0.08).
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CD45RA Distinguishes CD4+CD25+CD127-/low TSDR Demethylated Regulatory T Cell Subpopulations With Differential Stability and Susceptibility to Tacrolimus-Mediated Inhibition of Suppression.
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