Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample.

19 The association between either the unweighted or weighted genetic risk scores and self-reported ANM was highly significant with P values of 1.2 × 10 –61 and 2.2 × 10 –77 , respectively.

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Almost all were nominally significant (16 of 18) and all showed positive correlation with reported ANM, in agreement with their previously reported effects (Table 1 ). 19 The weighted gene risk score was 1.19 (Table 1 ) and the most significant gene locus was rs11668344 ( TMEM150B; P = 3.9 × 10 −20 ).

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