Across poliovirus types and vaccination groups our results furthermore showed a trend that subjects with lower pre-vaccination titres exhibited larger titre increases following the booster vaccine, Fig. 2 , Fig. 3 , Fig. 4 .
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First-in-human safety and immunogenicity investigations of three adjuvanted reduced dose inactivated poliovirus vaccines (IPV-Al SSI) compared to full dose IPV Vaccine SSI when given as a booster vaccination to adolescents with a history of IPV vaccination at 3, 5, 12months and 5years of age.
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