Combining omics data to identify genes associated with allergic rhinitis.

Given that DNA methylation may have an impact on gene regulation [ 5 ], the probability of detecting true positive associations should be improved by combining nominally significant data from genomics and epigenomics and linking them by quantitative trait loci (QTL) analysis.

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To identify new genes associated with this trait, we performed genome- and epigenome-wide association studies and linked marginally significant CpGs located in genes or its promoter and SNPs located 1 Mb from the CpGs, by identifying cis methylation quantitative trait loci (mQTL).

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