Age-related changes in the gene expression profile of antigen-specific mouse CD8+ T cells can be partially reversed by blockade of the BTLA/CD160 pathways during vaccination.

Levels of cell surface expressed NP epitope-specific TcR were slightly lower in aged CD8 + T cells although this difference failed to reach significance.

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Some differences were noted in transcripts encoding proteins involved in antigen presentation and processing or inflammatory responses without showing a clear trend toward higher or lower expression.

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