Impact of CD4+ T Cell Responses on Clinical Outcome following Oral Administration of Wild-Type Enterotoxigenic Escherichia coli in Humans.

We did not detect differences in B M responses between Resistant and Susceptible volunteers against any of the other antigens tested (CFA/I, LT-B, and dmLT) ( Fig 6B–6D ) We also found that higher integrin α4β7 expression by pT fh following stimulation with whole cell homogenate correlated with net IgA B M responses to LPS antigen on day 14 post-challenge (p = 0.025, linear regression) and approached significance on day 28 post-challenge (p = 0.08, linear regression) ( S6 Fig ).

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