Matrix-regulated integrin α<sub>v</sub>β<sub>5</sub> maintains α<sub>5</sub>β<sub>1</sub>-dependent desmoplastic traits prognostic of neoplastic recurrence.

Significant p-values in all figures were denoted by asterisks as follows: ****p<0.0001 extremely significant, ***p=0.0001–0.01 very significant, **p=0.01–0.05 significant and *p=0.05–0.10 marginally significant.

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We believe that future studies using larger numbers of samples and examining additional markers will result in significant protective OS outcomes, since we did observe some trends which did not reach statistical significance.

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