Radiation driven epithelial-mesenchymal transition is mediated by Notch signaling in breast cancer.

By analyzing multiple Notch ligands, we found that Jagged1 and DLL4 mRNA were increased significantly in irradiated MCF7 cells as compared to un-irradiated cells, whereas the smaller changes noted in Jagged2, and DLL1 transcripts did not reach statistical significance (Figure 3A ).

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