Genetic Contributors to Intergenerational CAG Repeat Instability in Huntington's Disease Knock-In Mice.

When controlling for CAG size using the adjustment method, we found a significantly reduced expansion frequency in Htt Q175neo+ (two-proportion z -test, P < 0.01), while the effect was only nominally significant when adjusting through the modeling methodology (two-proportion z -test, P = 0.03; Bonferroni corrected significance threshold P = 0.0167), likely due to the reduced sample size enforced by this methodology ( Figure 7D and Table S3 ).

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