Barely Significant
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Higher efficacy of anti-IL-6/IL-21 combination therapy compared to monotherapy in the induction phase of Th17-driven experimental arthritis.

PLoS One · 2017 · PMC5291406 · PMID 28158305

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a clear trendno p-value reported
Interestingly, a clear trend towards reduced Th17 levels in draining lymph nodes of mice receiving either early single or combination treatment was present, despite the late time point of analysis (day 35).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.