Homocysteine and the C677T Gene Polymorphism of Its Key Metabolic Enzyme MTHFR Are Risk Factors of Early Renal Damage in Hypertension in a Chinese Han Population.

The differences of the other clinical biochemistry indicators did not reach statistical significance ( P > 0.05) (Table 2 ).

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This study showed that patients with hypertension combined with early renal damage had higher levels of plasma homocysteine than hypertensive patients without renal damage (15.37 ± 13.21 μmol/L, 12.13 ± 4.70 μmol/L, P < 0.01); moreover, the UACR showed a positive correlation with plasma homocysteine ( r = 0.228, P < 0.01), which showed that with the increase of plasma homocysteine, urine microalbumin also showed an increasing trend.

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