a strong trendP = 0.062
Doppler measurements of blood flow across the mitral valve showed a detrimental increase in the myocardial performance index (MPI, a measure of combined systolic and diastolic function) in 10-week-old male SMGRKO mice ( P < 0.05), with a strong trend for an increase in MPI in females ( P = 0.062, Fig. 2 ).