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The impact of body composition parameters on ipilimumab toxicity and survival in patients with metastatic melanoma.

Br J Cancer · 2017 · PMC5294486 · PMID 28072766

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Patients with sarcopenia experienced more high-grade AEs compared with their non-sarcopenic counterparts (65% vs 34%, P =0.030, univariate OR=3.54, 95% CI: 1.23–10.17, P =0.019) and appeared to be more susceptible to a high-grade irAE (45% vs 25%); however, this did not reach statistical significance.

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