Folate and Vitamin B₁₂-Related Biomarkers in Relation to Brain Volumes.

Associations differed between the group that received B-vitamin supplementation and the group that did not ( Table 2 ), more specifically, interaction terms with treatment were significant or tended towards significance for MMA and grey matter ( p = 0.04), MMA and total brain volume ( p = 0.10), and Hcy and total brain volume ( p = 0.10).

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B-Vitamin Status and Brain MRI Volumes Fully adjusted linear regression models of biomarkers and brain volumes in the total population ( Table 2 ) showed an inverse association for serum folate with total brain volume (β = −0.20, 95% CI −0.34–−0.02; p = 0.03), and a borderline significant association with white matter volume (β = −0.17, 95% CI −0.34–0.01).

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