Galectin-3-null mice display defective neutrophil clearance during acute inflammation.

At 48 h after zymosan, total leukocyte counts were comparable for WT and Gal-3–null mice; however, at 72 h, there was a trend toward more leukocytes in the peritoneal cavities of Gal-3–null mice, although that increase did not reach statistical significance, and levels had declined to those observed in WT mice by 96 h ( Fig. 6A ).

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