Cystatin F is a biomarker of prion pathogenesis in mice.

In the hippocampus, Cst7 showed a trend toward upregulation at 110 and 123 dpi (≈3 fold and 10 fold, respectively), which reached statistical significance at 137 dpi (≈79 fold, p<0.05, One-way ANOVA, Dunnett’s Multiple Comparison Test) and at the terminal stage of disease (≈168 fold, p<0.001, One-way ANOVA, Dunnett’s Multiple Comparison Test; Fig 2C , S5 Table ).

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