Murine cytomegalovirus infection of mouse macrophages stimulates early expression of suppressor of cytokine signaling (SOCS)1 and SOCS3.

In contrast with the significant stimulation of SOCS1 and SOCS3 mRNA transcripts in IC-21 mouse macrophages during productive SG-MCMV infection, UVi-MCMV resulted in only a small trend toward transient stimulation of SOCS1 and SOCS3 that did not reach statistical significance when compared with medium-treated control cells ( Fig 3 ) and remained significantly lower than SG-MCMV values (SOCS1: p<0.05 for ≥2 hpi, and SOCS3: p<0.001 for 2 and 4 hpi, UVi-MCMV compared with SG-MCMV at each time point).

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