The expanded CAG repeat in the huntingtin gene as target for therapeutic RNA modulation throughout the HD mouse brain.

PLoS One · 2017 · PMC5300196 · PMID 28182673

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.0770

boldest claim

The sentences

a trend towards significancep = 0.053so close (0.05 < p ≤ 0.1)

This treatment effect was mostly attributable to the females, in which the high dose group showed a significant increase in vertical count at weeks 6, 8 and 12 and a trend towards significance in week 10 (p = 0.053).

also in 2,760 other papers

a positive trendp = 0.077so close (0.05 < p ≤ 0.1)

In cerebellum the reduction of soluble mHTT levels was less pronounced and there was more variation in the levels of the aggregated form of the mHTT protein, but nevertheless resulted in a positive trend towards reduction was observed for both mHTT protein forms after (CUG)7 administration (soluble: p = 0.077, aggregated: p = 0.066) ( S2B Fig ).

also in 11,005 other papers

did not reach statistical significanceno p-value reported

This shift towards WTs was also evident in males in the high dose group but did not reach statistical significance.

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.