A role for activated Cdc42 in glioblastoma multiforme invasion.

Activated Cdc42 decreases and inactive Cdc42 increases survival of glioma-bearing mice Induction of CA-Cdc42 in U251MG cells dramatically reduced the survival of mice compared to controls; from 97 to 56 days for U251MG ( p < 0.0001) (Figure 6A ), and from 66 to 50 days for U87MG xenografts, although the latter did not reach statistical significance ( p < 0.088) ( Supplementary Figure S2A ).

also in 111,027 other papers