Efficacy of otilonium bromide in irritable bowel syndrome: a pooled analysis.

However, the comparison between groups showed a favorable trend in the OB group in comparison with placebo, with significant differences at week 10 and week 15 by ANOVA and at week 15 by GLM ( p = 0.002) ( Figure 3 ).

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The comparison between treatment groups showed a trend for a greater reduction of stool frequency in the OB group in comparison with placebo, but without significant differences at any time point ( Figure 5 ).

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