Of note, the administration of rmMFG-E8 showed a trend suppressing the elevated expressions of TNF-α, IL-1β and IL-6 in 10% CSE stimulated RAW264.7 cells ( Fig. 5D–F ).
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Cigarette smoke attenuates phagocytic ability of macrophages through down-regulating Milk fat globule-EGF factor 8 (MFG-E8) expressions.
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