Renal ischemia/reperfusion-induced cardiac hypertrophy in mice: Cardiac morphological and morphometric characterization.

JRSM Cardiovasc Dis · 2017 · PMC5308538 · PMID 28228941

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ECM deposition is not only regulated by MMPs and TIMPs, but it is also a target for growth factors; therefore, we evaluated gene expression of TGF-β and FGF-2. TGF-β mRNA levels were decreased after 12 days of reperfusion ( Figure 4(g) , p < 0.05), whereas the analysis of FGF-2 mRNA levels did not show any significant changes, despite a clear trend to downregulation in all I/R groups.

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