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Topical tacrolimus for the treatment of secondary lymphedema.

Nat Commun · 2017 · PMC5309859 · PMID 28186091

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Late treatment with tacrolimus similarly increased nodal uptake (twofold); however, this difference did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.