Mitotic counts in breast cancer should be standardized with a uniform sample area.

There is a clear trend to less misclassification with greater sample areas and the misclassification rate has a non-linear relationship with the sample area where incremental increases in area have successively lower reductions in the misclassification rate, as shown by the flattening of the misclassification from 5 to 20 mm 2 (Table 4 ).

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