Diversity of Secondary Structure in Catalytic Peptides with β-Turn-Biased Sequences.

This nonideal H-bond may be coupled to the pronounced pyramidalization of the i +2 amide nitrogen-atom; N( i +2) deviates 0.14 Å from the plane defined by the N-substituents, which is quite significant compared to the 0.48 Å deviation in the corresponding tertiary amine moiety of the Dmaa residue. 48 On the other hand, conformer 7a does not exist as a β-hairpin in the solid state, even though this might be expected based on its near-canonical type II′ turn-motif and stereochemical array.

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