Early changes in emotional processing as a marker of clinical response to SSRI treatment in depression.

However, week 6 responders versus non-responders showed numerically greater improvements in HAM-D score after 7 days of treatment, although this did not reach statistical significance ( t =1.8, degree of freedom=32.3, P =0.08, Cohen's d' effect size 0.57). fMRI data At baseline, across all participants, fearful compared with happy faces activated a network of areas previously implicated in threat-relevant face processing.

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