nominally significantp < 0.05
We defined significant novel associations as those nominally significant (p < 0.05) in the replication study and with an overall (discovery and replication combined) p value <5 × 10 −8 .
We defined significant novel associations as those nominally significant (p < 0.05) in the replication study and with an overall (discovery and replication combined) p value <5 × 10 −8 .