Age-associated molecular changes are deleterious and may modulate life span through diet.

Compared to the young diet group, the old group exhibited a trend toward decreased life span (mean life-span difference, −6.1%), which did not reach statistical significance ( P = 0.2, log-rank test; Fig. 4A ).

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Although only a fraction of these dietary forms may be expected to be taken up by living organisms, the long-term effect of this treatment may be significant enough to affect life span.

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