Brain amyloid in preclinical Alzheimer's disease is associated with increased driving risk.

The model using just nonlinear functions of SUVR to account for the occurrence of violations or accidents has a pseudo- r 2 of 0.10 and is highly significant versus a null model ( P = .002).

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Lower levels (the direction of biomarker abnormality for CSF Aβ 42 ) of CSF Aβ 42 were also associated with increases in the number of driving errors, but this did not reach statistical significance ( P = .06), indicating overall that cognitively normal older adults with more AD-like biomarker values have worse driving performance.

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